UBIQBEST TABLET
OVERVIEW
Coenzyme Q10 (UBIQUINOL), a vitamin-like compound present throughout the body but predominantly in the heart, liver, kidney, and pancreas, can be obtained in small quantities from meats and seafood and can also be synthesized in a laboratory.
Primarily utilized for heart-related conditions like congestive heart failure (CHF), angina, and high blood pressure, Coenzyme Q10 is also employed to prevent ailments such as migraine headaches, Parkinson’s disease, and various other health issues.
How does it function?
Coenzyme Q10 plays a vital role as a vitamin-like substance necessary for the proper functioning of numerous organs and biochemical reactions in the body. It facilitates cellular energy production and exhibits antioxidant properties. Individuals with specific health conditions like heart failure, high blood pressure, gum disease, Parkinson’s disease, blood infections, certain muscular disorders, and HIV infection may have diminished levels of Coenzyme Q10.
USES
Possibly Effective for
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Heart failure and congestive heart failure (CHF):
Preliminary research suggests a potential link between low coenzyme Q10 levels and heart failure. Taking coenzyme Q10 orally may help reduce heart failure symptoms and lower the risk of related hospitalization or death. -
Diabetic neuropathy:
Studies indicate that coenzyme Q10 supplementation improves nerve damage and alleviates nerve pain in individuals with diabetes-related neuropathy. -
Fibromyalgia:
Oral intake of coenzyme Q10 has shown promise in reducing pain, tenderness, fatigue, and sleep issues in individuals with fibromyalgia. -
Ischemia-reperfusion injury:
Some evidence suggests that taking coenzyme Q10 before heart or blood vessel surgery may help mitigate tissue damage caused by reduced blood flow and subsequent restoration. -
Migraine:
Coenzyme Q10 supplementation by mouth appears effective in preventing migraine headaches in adults, with a reduction in migraine frequency observed in children after approximately 3 months. -
Multiple sclerosis (MS):
Oral administration of coenzyme Q10 seems to reduce tiredness and improve mood in individuals with MS. -
Muscular dystrophy:
In some cases, taking coenzyme Q10 orally has been associated with improved physical performance in individuals with muscular dystrophy. -
Heart attack:
Initiating coenzyme Q10 within 72 hours of a heart attack, and continuing for a year, appears to decrease the risk of heart-related events. -
Peyronie disease:
Research suggests that coenzyme Q10 may enhance erectile function in men experiencing painful erections.
Likely Ineffective for
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Athletic performance:
Oral intake of coenzyme Q10, alone or in combination with other ingredients, does not improve athletic performance in athletes or non-athletes. -
Huntington disease:
Large doses of coenzyme Q10 do not appear to halt the progression of symptoms in individuals with Huntington disease.
Insufficient Evidence for
- There is insufficient evidence to assess the effectiveness of coenzyme Q10 for numerous conditions, including chest pain (angina), heart damage from certain cancer drugs, autism, bipolar disorder, breast cancer, and many others. Further research is needed to establish its efficacy in these areas.
SIDE EFFECTS
Oral Consumption: Coenzyme Q10 is generally considered SAFE when taken by mouth for most adults. Although well-tolerated by many, mild side effects may occur, such as stomach upset, loss of appetite, nausea, vomiting, and diarrhea. Some individuals may experience allergic skin rashes. Notably, coenzyme Q10 could potentially lower blood pressure, particularly in individuals with already low blood pressure. It is advisable to monitor blood pressure carefully, especially for those with very low blood pressure. To minimize side effects, dividing the total daily dose and taking smaller amounts two or three times a day instead of a large single dose may be beneficial.
Special Precautions and Warnings
Oral Consumption: For most adults, taking Coenzyme Q10 by mouth is LIKELY SAFE. While generally well-tolerated, some individuals may experience mild side effects such as stomach upset, loss of appetite, nausea, vomiting, and diarrhea. Allergic skin rashes can occur in some cases. Additionally, it’s worth noting that Coenzyme Q10 might have a blood pressure-lowering effect, particularly in individuals with very low blood pressure. It is advisable to monitor blood pressure carefully, and dividing the total daily dose into smaller amounts taken two or three times a day can help minimize side effects.
Pregnancy and Breastfeeding: Coenzyme Q10 is POSSIBLY SAFE when taken by mouth appropriately during pregnancy. It has been used safely when taken twice daily starting at 20 weeks until delivery. However, there is insufficient information about the safety of Coenzyme Q10 during breastfeeding, so it is recommended to err on the side of caution and avoid its use.
Children: Coenzyme Q10 is POSSIBLY SAFE for children when taken by mouth, but it should not be used without medical supervision.
Interactions
Moderate Interaction – Be cautious with this combination
Medications for Cancer (Alkylating Agents): There is a potential interaction between Coenzyme Q10, an antioxidant, and medications used for cancer treatment, such as busulfan, carboplatin, cisplatin, cyclophosphamide (Cytoxan), dacarbazine, thiotepa, and others. While there is concern that antioxidants might reduce the effectiveness of cancer medications, more research is needed to confirm the interaction.
Warfarin (Coumadin): Coenzyme Q10 may interact with warfarin (Coumadin), a blood-thinning medication. Coenzyme Q10’s potential to increase blood clotting may counteract the effects of warfarin, potentially raising the risk of dangerous blood clots. Regular blood checks are crucial, and adjustments to the warfarin dosage may be necessary.
Minor Interaction – Be watchful with this combination
Medications for High Blood Pressure (Antihypertensive Drugs): Coenzyme Q10 has the potential to lower blood pressure. When taken alongside medications for high blood pressure, there is a possibility of blood pressure dropping excessively. Monitoring blood pressure closely and adjusting medication dosages under medical supervision is advisable. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and others.
Dosing
Recommended Doses Studied in Scientific Research for Adults:
Oral Administration
- Coenzyme Q10 Deficiency:
- Range: 150-2400 mg per day.
- Mitochondrial Myopathies (Group of Disorders Causing Muscle Weakness):
- Range: 150-160 mg per day or 2 mg/kg per day. In some cases, doses may be gradually increased to 3000 mg per day.
- Heart Failure and Congestive Heart Failure (CHF):
- 30 mg once daily, or up to 300 mg per day divided into two or three doses for up to 2 years.
- Alternatively, 2 mg/kg daily for up to one year has been used.
- Nerve Pain in People with Diabetes (Diabetic Neuropathy):
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- 400 mg per day for 12 weeks.
- Fibromyalgia:
- 300 mg daily for about 6 weeks.
- Alternatively, 200 mg twice daily for 3 months.
- Combination therapy: 200 mg of coenzyme Q10 (Bio-Quinon Q10, Pharma Nord) plus 200 mg of ginkgo (Bio-Biloba, Pharma Nord) per day for 12 weeks.
- INFERTILITY:
FEMALE: 100MG DAILY FOR THREE MONTHS
MALE: 300MG DAILY FOR THREE MONTHS
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Please note that these doses are based on scientific research studies, and individual responses to supplementation may vary. It is always recommended to consult with a healthcare professional before starting any new supplement regimen.