Intra-oral Vitamin Absorption Evidence and Case Studies

A sublingual vitamin D spray is an effective mode of delivery for supplementation in a healthy population.
Rapid and more consistent vitamin D delivery can be achieved through oral sprays compared to tablets.


Vitamin absorption via oral sprays is up to 2.6 times higher compared to soft gelatin capsules.
The buccal spray formulation was able to increase mean serum vitamin D3 concentration significantly higher as compared to the soft gelatin capsule, in both healthy subjects (1.9 times) as well as in patients with intestinal malabsorption syndrome (2.6 times).
A high dose vitamin D oral spray can dramatically increase vitamin D levels and resolve deficiency in healthy athletes.
High prevalence of vitamin D insufficiency and deficiency in collegiate Gaelic footballers during wintertime and such individuals should consider vitamin D supplementation to avoid being at risk of poor bone health. Twelve-week daily supplementation with a 3000 IU (75 µg) vitamin D3 oral spray solution is an appropriate method, dose and duration to resolve deficiency and increase total 25(OH)D concentrations to over 80 nmol/L. However, vitamin D supplementation, at the dose provided here for 12 weeks, did not have any beneficial effect on VO2 max, skeletal muscle or lung function in this cohort of Gaelic footballers.


Supplementation of vitamin D oral sprays significantly improved symptoms of IBS sufferers
The IBS population exhibits significant levels of vitamin D insufficiency and would benefit from screening and possible supplementation. The impact of IBS on quality of life may be reduced by vitamin D level.